Private area

The work plan has been divided into 4 Sub-Projects (SP) and 11 work packages (WPs).


SP No SP Title SP Description Activity
1 Management & Exploitation This SP concerns the management, dissemination and exploitation activities of the project, The SP will run Through out the total duration of the project MGM & OTHER
2 Requirements & Architecture The user requirements including clinical research and the architecture of the project will be developed in the SP. RTD
3 Development & Implementation The main ICT research and development effort will be carried out in this SP which will compose the kernel of the project RTD
4 Integration, Deployment and Demonstration The final integration of the platform and the demonstration activities will performed in the SP. RTD & DEM


SP WP WP Title Activity
1 WP1 Project Management MGM
1 WP2 Dissemination & Exploitation OTHER
2 WP3 User and Regulatory Requirements RTD
2 WP4 BioMEMs Specifications & Development RTD
2 WP5 Sensors & VAD Implementation RTD
3 WP6 Autoregulation Control Unit Development RTD
3 WP7 Remote Control Framework RTD
3 WP8 Decision Support System RTD
3 WP9 Training & Research Application RTD
4 WP10 Integration & Deployment RTD
4 WP11 Demonstration & Validation DEM


WP1 is responsible for the efficient and productive control of SensorART project. The parts that compose this workpackage are deal with administrative and technical management. Administrative management will promise the internal (inside consortium) and external (with EU) communication, the timely control of progress work, the quality of project deliverables and the efficient financial resource handling. Technical management is responsible for the deliverance of high quality and innovative results inside project’s time constraints and specified budget.

WP2’s objectives are:

  • To define an overall exploitation strategy taking in consideration the partners’ specific exploitation models
  • To identify internal and external factors affecting SensorART industrial perspectives
  • To define business models according to expected SensorART results;
  • To identify the exploitation environment (macro-environment and market type)
  • To analyze the project impact dimension and building the approach on sustainable development, in parallel with the expected results.
  • To evaluate the existing European legal and regulatory framework, to identify areas able to affect the immediate project’s development and applicability in the EU marketplace
  • To promote the awareness and, hence, the exploitation of the project’s results will be identified and pursued.
  • To identify potential stakeholders and promotion activities targeting communication of knowledge and potential project applications will be undertaken.


The objectives of WP3 are:

  • Define and analyze the specific user groups requirements
  • Describe the clinical validation plan
  • Search the time course of biological markers potentially involved in LVAD unfavorable response
  • Involve experts for regulatory requirements
  • Collect and analyse policies that represent the legal framework within SensorART will work.


The objectives of WP4 are:

  • Development of BioMEMs device that will base on a polymeric substrate and will integrate microsensors arrays and microfluidic, structure, which will be made on polydimethylsiloxane (PDMS). The immunosensor will be based on metallic micro/nanoelectrodes. The BioMEMs should allow the multiplexed detection and quantification of proteins by specific antibodies immobilized on gold micro/nanoelectrodes.
  • Develop the immobilisation procedures of antibodies onto functionalised gold micro/nanoelectrodes using Dip-pen nanolithography and to optimise the measurements criteria for impedance spectroscopy in order to achieve immunodetection of proteins in buffer solutions with a detection limit comparable with ELISA tests. The experimental conditions for working of an individual immunosensor will also be defined. Finally, electrochemical characterisation of the BioMEMs will be performed using blood containing soluble proteins.


WP5 integrates sensors and bio-sensors to meet biocompatibility standards of the VAD, develops a wireless power unit based on inductive coupling compelling with safety norms for variable magnetic fields exposure, releases a prototype for joint integration with the VAD controller and/or sensor nodes and reassures the interoperability and the expandability of the sensorized VAD.

The goal of WP6 is to develop a VAD independent autoregulation unit. The auto-regulation control algorithm will be implemented in an external and wearable hardware unit, which will be wirelessly linked to the implanted sensors and to the VAD actuators. This unit will allow to autoadjust the blood flow provided by the VAD to the patient’s heart according to signals coming from physical and physiological sensors. Moreover, this unit will monitor the energy consumption, as well as the VAD functionality, thus generating the appropriate crucial and vital alert messages. The autoregulation unit will be designed to allow interoperability among different VAD systems.

WP7 provides the Patient’s Monitoring Application, the Specialist’s Monitoring Application and tests and evaluates the capability of the developed applications to be used by the clinical workflow. WP8 provides the VAD – Heart simulation platform and the Specialist’s Decision Support System. WP9 provides the Training application based on patient-treatment scenarios, the Research application based on a data collection module and a research database and a Training Tool for personnel in charge for LVAD.

WP10 deals with?the implementation of efficient multi-parametric and adjustable monitoring interfaces, the development of a multi-variant user interface of the specialists’ decision support system which will assist the specialist deciding the best remote treatment procedure and with the tests, integration and delivery of the final SensorART products by deploying the research?products with the intelligent decision support algorithms.

Finally, WP11 contains the following activities:

  • Acute and chronic animal experiment on sheep and pig models in order to:
    • Verify the feasibility
    • Verify the stability of sensors in time in life condition
    • Assess the biological variability in chronic conditions
    • Check possible biocompatibility issues (mechanical wear, histopathological changes).
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